Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
RPA binds to the Flap on the C-strand
Stable Identifier
R-HSA-174445
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Processive synthesis on the C-strand of the telomere (Homo sapiens)
Removal of the Flap Intermediate from the C-strand (Homo sapiens)
RPA binds to the Flap on the C-strand (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The first step in the removal of the flap intermediate is the binding of Replication Protein A (RPA) to the long flap structure. RPA is a eukaryotic single-stranded DNA binding protein (Bae et al. 2001). Binding of RPA to the single strand DNA during telomeric strand displacement synthesis is necessary for the recruitment of DNA2. DNA2 is a helicase/endonuclease that resolves G quadruplexes (G4), which are DNA structures that commonly form in polyguanine-rich telomeric DNA sequences (Masuda-Sasa et al. 2008). DNA2 also removes the initiator RNA primers of Okazaki fragments (Bae et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
18593712
Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition
Peng, XP
,
Masuda-Sasa, T
,
Polaczek, P
,
Chen, L
,
Campbell, JL
J. Biol. Chem.
2008
Participants
Input
Processive complex loaded on telomere:Okazaki fragment:Flap [nucleoplasm]
(Homo sapiens)
RPA heterotrimer [nucleoplasm]
(Homo sapiens)
Output
Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Removal of the Flap Intermediate from the C-strand (Homo sapiens)
Event Information
Go Biological Process
telomere maintenance via semi-conservative replication (0032201)
Orthologous Events
RPA binds to the Flap on the C-strand (Bos taurus)
RPA binds to the Flap on the C-strand (Canis familiaris)
RPA binds to the Flap on the C-strand (Mus musculus)
RPA binds to the Flap on the C-strand (Rattus norvegicus)
RPA binds to the Flap on the C-strand (Sus scrofa)
Authored
Blackburn, EH (2006-03-10)
Seidel, J (2006-03-10)
Reviewed
Hayashi, MT (2020-04-29)
Price, C (2006-07-13)
Created
Gillespie, ME (2006-02-18)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text