Removal of the Flap Intermediate from the C-strand

Stable Identifier
R-HSA-174437
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Removal of the Flap Intermediate from the C-strand
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Two endonucleases, Dna2 and flap endonuclease 1 (FEN-1), are responsible for resolving the nascent flap structure (Tsurimoto and Stillman 1991). The Dna2 endonuclease/helicase in yeast is a monomer of approximately 172 kDa. Human FEN-1 is a single polypeptide of approximately 42 kDa. Replication Protein A regulates the switching of endonucleases during the removal of the displaced flap (Tsurimoto et al.1991).
Literature References
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
telomere maintenance via semi-conservative replication (0032201)
Orthologous Events
Removal of the Flap Intermediate from the C-strand (Bos taurus)
Removal of the Flap Intermediate from the C-strand (Canis familiaris)
Removal of the Flap Intermediate from the C-strand (Mus musculus)
Removal of the Flap Intermediate from the C-strand (Rattus norvegicus)
Removal of the Flap Intermediate from the C-strand (Schizosaccharomyces pombe)
Removal of the Flap Intermediate from the C-strand (Sus scrofa)
Authored
Blackburn, EH  (2006-03-10)
Seidel, J  (2006-03-10)
Reviewed
Hayashi, MT  (2020-04-29)
Price, C  (2006-07-13)
Created
Gillespie, ME  (2006-02-18)
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