Telomere C-strand synthesis initiation

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R-HSA-174430
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Homo sapiens
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DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA. There have been reports that TRF1 inhibits this activity at telomeres, though the mechanism and physiological relevance of this inhibition remain to be elucidated.

Literature References
PubMed ID Title Journal Year
11327863 TRF1 inhibits telomere C-strand DNA synthesis in vitro

Smucker, EJ, Turchi, JJ

Biochemistry 2001
11395402 DNA primases.

Frick, DN, Richardson, CC

Annu Rev Biochem 2002
6693436 DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.

Wang, TS, Hu, SZ, Korn, D

J Biol Chem 1984
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