Degradation multiubiquitinated Cyclin A

Stable Identifier
R-HSA-174255
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Following multiubiquitination, Cyclin A is targeted for destruction by the 26S proteasome.

Literature References
PubMed ID Title Journal Year
11285280 Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint

Geley, S, Kramer, E, Gieffers, C, Gannon, J, Peters, JM, Hunt, T

J Cell Biol 2001
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created