Reactome | Cdc20:Phospho-APC/C mediated degradation of Cyclin A

Cdc20:Phospho-APC/C mediated degradation of Cyclin A

Stable Identifier

R-HSA-174184

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Cdc20:Phospho-APC/C mediated degradation of Cyclin A

Click the image above or here to open this pathway in the Pathway Browser

Cyclin A, functions in mitosis as well as DNA replication and is degraded in the interim by the APC/C to permit normal chromosome segregation, cell division, and the onset of S phase (see Lukas and Bartek, 2004). Cyclin A is initially degraded early in mitosis by APC/C:Cdc20 when the spindle checkpoint is still active and degradation of securin and cyclin B is inhibited.

Literature References

PubMed ID	Title	Journal	Year
11285280	Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint Peters, JM, Gannon, J, Geley, S, Kramer, E, Gieffers, C, Hunt, T	J Cell Biol	2001