Degradation of multiubiquitinated cell cycle proteins

Stable Identifier
R-HSA-174105
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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General
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Cell cycle proteins mulitubiquitinated by the APC/C are targeted for degradation by the 26S proteasome.

Literature References
PubMed ID Title Journal Year
16413484 The processivity of multiubiquitination by the APC determines the order of substrate degradation

Rape, M, Reddy, SK, Kirschner, MW

Cell 2006
15678131 The anaphase-promoting complex: a key factor in the regulation of cell cycle

Castro, A, Bernis, C, Vigneron, S, Labbe, JC, Lorca, T

Oncogene 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created