Properdin stabilizes C3b:Bb bound to cell surfaces

Stable Identifier
R-HSA-173754
Type
Reaction [binding]
Species
Homo sapiens
Compartment
external side of plasma membrane
ReviewStatus
5/5
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Properdin stabilizes C3b:Bb bound to cell surfaces
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C3b:Bb is naturally labile with a half-life of ~90 s; association of the complex with properdin extends the half-life to ~30 min. (Medicus et al. 1976). Properdin is found in the blood as a mixture of multivalent oligomers: 30% dimers, 45% trimers, 10% tetramers, and 15% higher oligomers. Monomers associate with one another in a head-to-tail arrangement, producing closed circular structures (Smith et al. 1984; Alcorlo M et al. 2013). These features suggest that the properdin oligomer associated with a C3b:Bb complex on a surface such as a cell membrane can facilitate recruitment of additional C3b:Bb complexes to the site (Farries et al. 1988; Hourcade 2006).
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Orthologous Events
Properdin stabilizes C3b:Bb bound to cell surfaces (Bos taurus)
Properdin stabilizes C3b:Bb bound to cell surfaces (Canis familiaris)
Properdin stabilizes C3b:Bb bound to cell surfaces (Danio rerio)
Properdin stabilizes C3b:Bb bound to cell surfaces (Mus musculus)
Properdin stabilizes C3b:Bb bound to cell surfaces (Sus scrofa)
Properdin stabilizes C3b:Bb bound to cell surfaces (Xenopus tropicalis)
Authored
de Bono, B  (2004-08-04)
Reviewed
D'Eustachio, P  (2006-07-04)
Created
de Bono, B  (2006-02-16)
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