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C8G [extracellular region]
Stable Identifier
R-HSA-173712
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
C8 Gamma
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
CD59 inhibits MAC formation (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
CD59:C5b-C9 [plasma membrane] (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
Clusterin binds C5b-C7, C8, C9 (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
Formation of soluble VTN:C5b-C9 (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
VTN:C5b:C6:C7:C8:C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
Terminal pathway of complement (Homo sapiens)
C5b:C6:C7 translocates to the plasma membrane (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
C7 binds C5b:C6 (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
C8 binds C5b:C6:C7 (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
C9 binds C5b:C6:C7:C8 (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
Membrane Attack Complex [plasma membrane] (Homo sapiens)
C8 [extracellular region] (Homo sapiens)
C8G [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07360 C8G
Gene Names
C8G
Chain
signal peptide:1-20, chain:21-202
Reference Genes
BioGPS Gene:733 C8G
COSMIC (genes):C8G C8G
CTD Gene:733 C8G
dbSNP Gene:733 C8G
ENSEMBL:ENSG00000176919 C8G
HGNC:1354 C8G
KEGG:hsa:733 C8G
Monarch:733 C8G
NCBI Gene:733 C8G
OMIM:120930 C8G
UCSC:P07360 C8G
Reference Transcript
RefSeq:NM_000606.2 C8G
Other Identifiers
11731854_at
17091465
210324_PM_at
210324_at
3194970
3194971
3194972
3194973
3194974
3194975
3194976
3194977
3194978
3194979
3194980
3194981
3194982
3194983
3194984
3194985
35524_at
733
8159491
A_23_P20713
A_33_P3262020
A_33_P3319006
GO:0001848
GO:0002376
GO:0005515
GO:0005576
GO:0005579
GO:0005615
GO:0005886
GO:0006956
GO:0006957
GO:0006958
GO:0008289
GO:0019841
GO:0031640
GO:0043226
GO:0044877
GO:0050778
GO:0070062
GO:0072562
GO:0098542
HMNXSV003058457
ILMN_1737242
PH_hs_0000171
TC09000828.hg
U08198_rna1_at
g179723_3p_at
Participates
as a component of
C8 [extracellular region] (Homo sapiens)
Inferred To
C8G [extracellular region]
(Bos taurus)
C8G [extracellular region]
(Canis familiaris)
C8G [extracellular region]
(Gallus gallus)
C8G [extracellular region]
(Sus scrofa)
C8g [extracellular region]
(Mus musculus)
Cross References
RefSeq
NP_000597.2
ENSEMBL
ENST00000371634
,
ENSP00000360697
OpenTargets
ENSG00000176919
HPA
ENSG00000176919-C8G
PRO
P07360
Pharos - Targets
P07360
Orphanet
C8G
PDB
8B0H
,
7NYD
,
8B0F
,
2QOS
,
8B0G
,
3OJY
,
7NYC
,
6H03
,
2RD7
,
1LF7
,
6H04
,
1IW2
,
2OVD
,
2OVA
,
2OVE
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01031 C5
7
C5a [extracellular region]
(R-HSA-173677)
C5 beta chain [extracellular region]
(R-HSA-173675)
C5 alpha chain [extracellular region]
(R-HSA-173673)
C5b alpha' [extracellular region]
(R-HSA-173672)
C5a-desArg [extracellular region]
(R-HSA-8852798)
C5aT [extracellular region]
(R-HSA-8852711)
C5(965-1676) [extracellular region]
(R-HSA-8852713)
0.553
2
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