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What is Reactome ?
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p-TGFBR1 [plasma membrane]
Stable Identifier
R-HSA-170863
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Phospho-TGF-beta I receptor complex
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
Loss of Function of SMAD2/3 in Cancer (Homo sapiens)
SMAD2/3 Phosphorylation Motif Mutants in Cancer (Homo sapiens)
Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 Phosphorylation Motif Mutants [early endosome membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
BAMBI interferes with the interaction of type I receptor with type II receptor (Homo sapiens)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
Degradation of TGF-beta receptor complex (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
PP1 dephosphorylates TGFBR1 (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
STRAP binds phosphorylated TGF-beta receptor complex (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Homo sapiens)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
UCHL5 binds SMAD7 in complex with ubiquitinated TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
UCHL5, USP15 deubiquitinate TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7:UCHL5/USP15 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:Ub-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 phosphorylates TGFBR1 (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
Disassembly of tight junctions (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
SMURF1 binds phosphorylated PARD6A (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
SMURF1 ubiquitinates RHOA (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
p-TGFBR1 [plasma membrane] (Homo sapiens)
Participants
components
x 2
p-4S,T185,T186-TGFBR1 [plasma membrane]
(Homo sapiens)
Participates
as a component of
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 Phosphorylation Motif Mutants [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:Smad7 [plasma membrane] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
Inferred To
p-TGFBR1 [plasma membrane]
(Bos taurus)
p-TGFBR1 [plasma membrane]
(Caenorhabditis elegans)
p-TGFBR1 [plasma membrane]
(Canis familiaris)
p-TGFBR1 [plasma membrane]
(Danio rerio)
p-TGFBR1 [plasma membrane]
(Drosophila melanogaster)
p-TGFBR1 [plasma membrane]
(Gallus gallus)
p-TGFBR1 [plasma membrane]
(Mus musculus)
p-TGFBR1 [plasma membrane]
(Rattus norvegicus)
p-TGFBR1 [plasma membrane]
(Sus scrofa)
p-TGFBR1 [plasma membrane]
(Xenopus tropicalis)
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