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TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
Stable Identifier
R-HSA-171180
Type
Complex
Species
Homo sapiens
Compartment
early endosome membrane
Synonyms
TGFB1:p-TGFBR:SARA:p-2S-SMAD2,3, TGFB1:p-TGFBR:SARA:p-S465,467-SMAD2,p-S423,425-SMAD3, TGFB1:TGFBR2:p-5S-T185-TGFBR1:SARA:p-S465,467-SMAD2,p-S423,425-SMAD3, TGF-beta 1:type II receptor:Phospho-type I receptor:SARA:Phospho-R-SMAD complex
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
Participants
components
Dimeric TGFB1 [extracellular region]
(Homo sapiens)
p-2S-SMAD2,3 [cytosol]
(Homo sapiens)
p-TGFBR1 [plasma membrane]
(Homo sapiens)
TGFBR2 homodimer [plasma membrane]
(Homo sapiens)
ZFYVE9-1 [early endosome membrane]
(Homo sapiens)
Participates
as an output of
Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)
as an input of
Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)
Inferred To
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
(Bos taurus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
(Caenorhabditis elegans)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
(Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
(Danio rerio)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
(Drosophila melanogaster)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
(Gallus gallus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
(Mus musculus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
(Rattus norvegicus)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane]
(Sus scrofa)
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