TGFBR2 recruits TGFBR1

Stable Identifier
Reaction [transition]
Homo sapiens
Type II receptor recruits type I receptor
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The protein complex of dimeric TGF-beta-1 with the type II receptor dimer (dimeric TGFB1:TGFBR2 homodimer) recruits the low affinity receptor, type I receptor (TGFBR1), thus forming a hetero-tetrameric receptor bound to the dimeric ligand on the extracellular face of the plasma membrane (TGFB1:TGFBR2:TGFBR1) (Wrana et al. 1992, Moustakas et al. 1993, Franzen et al. 1993). FKBP1A (FKBP12), a peptidyl-prolyl cis-trans isomerase, forms a complex with TGFBR1 and prevents phosphorylation of TGFBR1 by TGFBR2 in the absence of ligand. FKBP1A dissociates from TGFBR1 after it forms a complex with ligand-activated TGFBR2 (Chen et al. 1997). TGFBR1 can homodimerize in the absence of TGFB1 when overexpressed, but under physiological conditions it exists as a monomer on the surface of unstimulated cells. TGFB1-induced dimerization of TGFBR1 is TGFBR2-dependent (Zhang et al. 2010). Also, TGFBR3, a glycoprotein, binds primarily to TGFB2 and facilitates the TGFBR2 binding with its ligand and also its binding with TGFBR1 by bringing ligands in close proximity to TGFBR2 (Lopez-Casillas et al. 1993, Blobe et al. 2001).
Literature References
PubMed ID Title Journal Year
8242743 Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor

Miyazono, K, Schulz, P, Yamashita, H, Ichijo, H, ten Dijke, P, Heldin, CH, Franzen, P

Cell 1993
7693660 The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand

O'Connor-McCourt, MD, Lodish, HF, Plamondon, J, Henis, YI, Moustakas, A, Lin, HY

J Biol Chem 1993
1333888 TGF beta signals through a heteromeric protein kinase receptor complex

Massague, J, Wrana, JL, Carcamo, J, Laiho, M, Attisano, L, Doody, J, Wang, XF, Zentella, A

Cell 1992
9233797 Mechanism of TGFbeta receptor inhibition by FKBP12

Massague, J, Liu, F, Chen, YG

EMBO J 1997
20625381 Monomeric type I and type III transforming growth factor-? receptors and their dimerization revealed by single-molecule imaging

Xu, L, Yuan, J, Chen, YG, Wang, Q, Zuo, W, Zhang, W, Fang, X, Yang, Y

Cell Res. 2010
This event is regulated
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