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Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
Stable Identifier
R-HSA-170865
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Dimeric TGF-beta1:type II receptor complex
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
Loss of Function of TGFBR1 in Cancer (Homo sapiens)
TGFBR1 LBD Mutants in Cancer (Homo sapiens)
TGFBR2 does not recruit TGFBR1 LBD Mutants (Homo sapiens)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Dimeric TGF-beta-1 binds to the receptor (Homo sapiens)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGFBR2 recruits TGFBR1 (Homo sapiens)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Homo sapiens)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Homo sapiens)
Participants
components
Dimeric TGFB1 [extracellular region]
(Homo sapiens)
TGFBR2 homodimer [plasma membrane]
(Homo sapiens)
Participates
as an input of
TGFBR2 does not recruit TGFBR1 LBD Mutants (Homo sapiens)
TGFBR2 is recruited to tight junctions-associated, Pard6a-bound, TGFBR1 after TGF-beta stimulation (Homo sapiens)
TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)
TGFBR2 recruits TGFBR1 (Homo sapiens)
as an output of
Dimeric TGF-beta-1 binds to the receptor (Homo sapiens)
Inferred To
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
(Bos taurus)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
(Caenorhabditis elegans)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
(Canis familiaris)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
(Danio rerio)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
(Drosophila melanogaster)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
(Gallus gallus)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
(Mus musculus)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
(Rattus norvegicus)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane]
(Sus scrofa)
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