Reactome | p-NELFE [nucleoplasm]

p-NELFE [nucleoplasm]

Stable Identifier

R-HSA-170698

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-RDBP, phospho-RD

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Transcription of the HIV genome (Homo sapiens)
        
        HIV Transcription Elongation (Homo sapiens)
        
        Tat-mediated elongation of the HIV-1 transcript (Homo sapiens)
        
        Addition of nucleotides leads to HIV-1 transcript elongation (Homo sapiens)
        
        HIV-1 elongation complex containing Tat [nucleoplasm] (Homo sapiens)
        
        Tat-containing early elongation complex with hyperphosphorylated Pol II CTD ( phospho-NELF phospho DSIF) [nucleoplasm] (Homo sapiens)
        
        phospho-NELF complex [nucleoplasm] (Homo sapiens)
        
        p-NELFE [nucleoplasm] (Homo sapiens)
        
        Formation of HIV-1 elongation complex containing HIV-1 Tat (Homo sapiens)
        
        Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
        
        Tat-containing early elongation complex with hyperphosphorylated Pol II CTD and phospho-NELF [nucleoplasm] (Homo sapiens)
        
        phospho-NELF complex [nucleoplasm] (Homo sapiens)
        
        p-NELFE [nucleoplasm] (Homo sapiens)
        
        Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)
        
        Tat-containing early elongation complex with hyperphosphorylated Pol II CTD ( phospho-NELF phospho DSIF) [nucleoplasm] (Homo sapiens)
        
        phospho-NELF complex [nucleoplasm] (Homo sapiens)
        
        p-NELFE [nucleoplasm] (Homo sapiens)
        
        Tat-containing early elongation complex with hyperphosphorylated Pol II CTD and phospho-NELF [nucleoplasm] (Homo sapiens)
        
        phospho-NELF complex [nucleoplasm] (Homo sapiens)
        
        p-NELFE [nucleoplasm] (Homo sapiens)
        
        Recruitment of elongation factors to form HIV-1 elongation complex (Homo sapiens)
        
        HIV-1 elongation complex containing Tat [nucleoplasm] (Homo sapiens)
        
        Tat-containing early elongation complex with hyperphosphorylated Pol II CTD ( phospho-NELF phospho DSIF) [nucleoplasm] (Homo sapiens)
        
        phospho-NELF complex [nucleoplasm] (Homo sapiens)
        
        p-NELFE [nucleoplasm] (Homo sapiens)
        
        Tat-containing early elongation complex with hyperphosphorylated Pol II CTD ( phospho-NELF phospho DSIF) [nucleoplasm] (Homo sapiens)
        
        phospho-NELF complex [nucleoplasm] (Homo sapiens)
        
        p-NELFE [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18615 NELFE

Gene Names

NELFE, RD, RDBP

Chain

chain:1-380

Reference Genes

BioGPS Gene:7936 NELFE

COSMIC (genes):NELFE NELFE

CTD Gene:7936 NELFE

dbSNP Gene:7936 NELFE

ENSEMBL:ENSG00000204356 NELFE

HGNC:13974 NELFE

KEGG:hsa:7936 NELFE

Monarch:7936 NELFE

NCBI Gene:7936 NELFE

OMIM:154040 NELFE

UCSC:P18615 NELFE

Reference Transcript

RefSeq:NM_002904.5 NELFE

Other Identifiers

11744211_a_at

11744949_a_at

17017575

17017600

17029432

17029454

17032218

17032240

17036925

17036947

17039668

17039690

17042173

17042195

209219_PM_at

209219_at

2948763

2948764

2948765

2948766

2948767

2948768

2948769

2948770

2948771

2948772

2948773

2948774

2948775

2948776

2948777

2948778

2948779

2948780

2948781

2948782

41407_at

7936

8125204

8178686

8179913

A_23_P122545

A_24_P849628

GE79511

GO:0000122

GO:0000785

GO:0003676

GO:0003682

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005886

GO:0006355

GO:0016604

GO:0031401

GO:0032021

GO:0034244

GO:0043226

GO:0045944

GO:0070374

HMNXSV003000966

HMNXSV003021709

ILMN_1765532

L03411_s_at

PH_hs_0019794

TC06001552.hg

TC6_cox_hap2000180.hg

TC6_dbb_hap3000169.hg

TC6_mcf_hap5000155.hg

TC6_qbl_hap6000170.hg

TC6_ssto_hap7000148.hg

X99296_xpt1_at

g190973_3p_at

Participates

as a component of

phospho-NELF complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

NELFE [nucleoplasm]

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_002895.3

OpenTargets

ENSG00000204356

ENSEMBL

ENST00000383174, ENST00000383343, ENST00000429857, ENST00000444811, ENST00000448628, ENSP00000372834, ENSP00000394879, ENSP00000388400, ENST00000457397, ENSP00000393005, ENSP00000364574, ENSP00000403623, ENSP00000364578, ENSP00000372660, ENST00000375425, ENST00000375429

HPA

ENSG00000204356-NELFE

PRO

P18615

Pharos - Targets

P18615

GlyGen

P18615

PDB

2BZ2, 8W8E, 8JJ6, 1X5P, 7YCX, 5OOB, 8UHG, 8UI0, 8UHA, 6GML, 2JX2, 8UHD

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WX92 NELFB	3	NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [cytosol] (R-HSA-9603526) NELFB [nucleoplasm] (R-HSA-112427)	0.906	9
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.812	9
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.65	4
UniProt:P52298 NCBP2	2	NCBP2 [cytosol] (R-HSA-162458) NCBP2 [nucleoplasm] (R-HSA-51463)	0.643	4
UniProt:Q8IXH7-4 NELFCD			0.643	3
UniProt:Q8WX92-2 Q8WX922			0.556	7
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:Q2TAC2 CCD57			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:Q8IXH7 NELFCD	1	NELFCD [nucleoplasm] (R-HSA-112428)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	4
UniProt:P38935 SMBP2			0.527	3