Phosphorylation of ARMS by Trk receptor (on tyrosine 1096) enables ARMS to recruit Crk via it's SH2 domain and freeing the SH3 domain. The SH3 domain of Crk is then free to bind C3G for MAP kinase activation.
Arevalo, JC, Pereira, DB, Yano, H, Teng, KK, Chao, MV
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