ARMS is phosphorylated by active TrkA receptor

Stable Identifier
R-HSA-169905
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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ARMS is phosphorylated by active TrkA receptor
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Phosphorylation of ARMS by Trk receptor (on tyrosine 1096) enables ARMS to recruit Crk via it's SH2 domain and freeing the SH3 domain. The SH3 domain of Crk is then free to bind C3G for MAP kinase activation.

Literature References
PubMed ID Title Journal Year
16284401 Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation

Arevalo, JC, Pereira, DB, Yano, H, Teng, KK, Chao, MV

J Biol Chem 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of Active TrkA receptor:ARMS:Crk complex [plasma membrane]
Physical Entity
Active TrkA receptor:ARMS:Crk complex [plasma membrane]
Activity
transmembrane receptor protein tyrosine kinase activity (0004714)
Orthologous Events
ARMS is phosphorylated by active TrkA receptor (Bos taurus)
ARMS is phosphorylated by active TrkA receptor (Canis familiaris)
ARMS is phosphorylated by active TrkA receptor (Danio rerio)
ARMS is phosphorylated by active TrkA receptor (Mus musculus)
ARMS is phosphorylated by active TrkA receptor (Rattus norvegicus)
ARMS is phosphorylated by active TrkA receptor (Sus scrofa)
ARMS is phosphorylated by active TrkA receptor (Xenopus tropicalis)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2005-12-16)
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