ARMS is phosphorylated by active TrkA receptor

Stable Identifier
R-HSA-169905
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation of ARMS by Trk receptor (on tyrosine 1096) enables ARMS to recruit Crk via it's SH2 domain and freeing the SH3 domain. The SH3 domain of Crk is then free to bind C3G for MAP kinase activation.

Literature References
PubMed ID Title Journal Year
16284401 Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation

Arevalo, JC, Pereira, DB, Yano, H, Teng, KK, Chao, MV

J Biol Chem 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of Active TrkA receptor:ARMS:Crk complex [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created