Reactome | Crk's SH3 domain engages C3G

Crk's SH3 domain engages C3G

Stable Identifier

R-HSA-169895

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Prolonged ERK activation events (Homo sapiens)
        
        ARMS-mediated activation (Homo sapiens)
        
        Crk's SH3 domain engages C3G (Homo sapiens)

General

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Rap guanine nucleotide exchange factor 1 (RAPGEF1, C3G) is a guanine nucleotide exchange factor for Rap1, which is recruited by Crk adaptor proteins (Knudsen et al. 1994; York, 1998).

Literature References

PubMed ID	Title	Journal	Year
16284401	Identification of a switch in neurotrophin signaling by selective tyrosine phosphorylation Arevalo, JC, Pereira, DB, Yano, H, Teng, KK, Chao, MV	J Biol Chem	2006