Reactome | Toll Like Receptor TLR6:TLR2 Cascade

Toll Like Receptor TLR6:TLR2 Cascade

Stable Identifier

R-HSA-168188

Type

Pathway

Species

Homo sapiens

Related Species

Neisseria meningitidis serogroup B, Chlamydia trachomatis

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TLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recognizing peptidoglycan wall products from Gram-positive bacteria, as well as Mycobacterial diacylated lipopeptides. In particular, TLR6 appears to participate in discriminating the subtle differences between dipalmitoyl and tripalmitoyl cysteinyl residues (Okusawa et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14977973	Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6 Okusawa, T, Fujita, M, Nakamura, J, Into, T, Yasuda, M, Yoshimura, A, Hara, Y, Hasebe, A, Golenbock, DT, Morita, M, Kuroki, Y, Ogawa, T, Shibata, K	Infect Immun	2004