Binding of vRNP:M1:NEP complex to CRM1 export receptor

Stable Identifier
R-HSA-168857
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
nucleoplasm
ReviewStatus
5/5
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Binding of vRNP:M1:NEP complex to CRM1 export receptor
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Virus NEP/NS2 interacts with human CRM1 (hCRM1), possibly dependent on a nuclear export signal (NES) motif in the NEP/NS2 N-terminal region (O'Neill, 1998; Neumann, 2000). The CRM1/exportin-1 pathway is a cellular mechanism for nuclear export, with CRM1 interacting with the Ran small GTPase and a cargo molecule's leucine-rich NES (Fukuda, 1997; Petosa, 2004). Leptomycin B, which specifically inhibits hCRM1, blocks export of viral RNP (Elton, 2001; Ma, 2001; Watanabe, 2001). Thus, NEP/NS2 interaction with cellular nuclear export machinery is essential for nuclear export of vRNP complexes and influenza virus release. A role for NP protein interaction with export machinery has also been proposed (Elton, 2001).
Literature References
PubMed ID Title Journal Year
11118210 Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1

Neumann, G, Hughes, MT, Kawaoka, Y

EMBO J 2000
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
intracellular transport of virus (0075733)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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