Binding of vRNP:M1:NEP complex to CRM1 export receptor

Stable Identifier
R-HSA-168857
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
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General
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Virus NEP/NS2 interacts with human CRM1 (hCRM1), possibly dependent on a nuclear export signal (NES) motif in the NEP/NS2 N-terminal region (O'Neill, 1998; Neumann, 2000). The CRM1/exportin-1 pathway is a cellular mechanism for nuclear export, with CRM1 interacting with the Ran small GTPase and a cargo molecule's leucine-rich NES (Fukuda, 1997; Petosa, 2004). Leptomycin B, which specifically inhibits hCRM1, blocks export of viral RNP (Elton, 2001; Ma, 2001; Watanabe, 2001). Thus, NEP/NS2 interaction with cellular nuclear export machinery is essential for nuclear export of vRNP complexes and influenza virus release. A role for NP protein interaction with export machinery has also been proposed (Elton, 2001).

Literature References
PubMed ID Title Journal Year
11118210 Influenza A virus NS2 protein mediates vRNP nuclear export through NES-independent interaction with hCRM1

Neumann, G, Hughes, MT, Kawaoka, Y

EMBO J 2000
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Created