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Concerted hemagglutinin pore formation
Stable Identifier
R-HSA-168306
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
endocytic vesicle membrane
,
endosome lumen
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Fusion and Uncoating of the Influenza Virion (Homo sapiens)
Fusion of the Influenza Virion to the Host Cell Endosome (Homo sapiens)
Concerted hemagglutinin pore formation (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The concerted structural change of several hemagglutinin molecules opens a pore through which the viral RNP will be able to pass into the host cell cytosol.
Literature References
PubMed ID
Title
Journal
Year
3663665
Fusion of influenza virus in an intracellular acidic compartment measured by fluorescence dequenching
Wilschut, J
,
Scholma, J
,
Stegmann, T
,
Morselt, HW
Biochim Biophys Acta
1987
Participants
Input
Influenza A Viral Particle Docked At The Endocytic Vesicle Membrane [endocytic vesicle membrane]
(Influenza A virus)
Output
Influenza A Viral Particle Docked At The Endocytic Vesicle Membrane With An Open Pore [endocytic vesicle membrane]
(Influenza A virus)
Participates
as an event of
Fusion of the Influenza Virion to the Host Cell Endosome (Homo sapiens)
Event Information
Go Biological Process
fusion of virus membrane with host plasma membrane (0019064)
Disease
Name
Identifier
Synonyms
influenza
DOID:8469
Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Created
© 2025
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