Fusion of the Influenza Virion to the Host Cell Endosome

Stable Identifier
R-HSA-168288
Type
Pathway
Species
Homo sapiens
Related Species
Influenza A virus
ReviewStatus
5/5
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Fusion of the Influenza Virion to the Host Cell Endosome
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After the virus binds to the target cell surface and is endocytosed, the low pH of the endosome causes the viral HA (hemagglutinin) to undergo a structural change which frees the fusion peptide of its HA2 subunit allowing it to interact with the endosome membrane. The transmembrane domain of the HA2 (inserted into the viral membrane) and the fusion peptide (inserted into the endosomal membrane) are in juxtaposition in the acidic pH structure of HA. The concerted structural change of several hemagglutinin molecules then opens a pore through which the viral RNP will be able to pass into the host cell cytosol.
Literature References
PubMed ID Title Journal Year
2500008 Virus entry into animal cells

Marsh, M, Helenius, A

Adv Virus Res 1989
15609499 Viral entry

Whittaker, GR, Sieczkarski, SB

Curr Top Microbiol Immunol 2005
3663665 Fusion of influenza virus in an intracellular acidic compartment measured by fluorescence dequenching

Wilschut, J, Scholma, J, Stegmann, T, Morselt, HW

Biochim Biophys Acta 1987
Participants
Events
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as an event of
Event Information
Go Biological Process
fusion of virus membrane with host plasma membrane (0019064)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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