Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18

Stable Identifier
R-HSA-1678841
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
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Ubiquitin specific protease 18 (USP18/UBP43) is the major ISG15 deconjugating enzyme. It removes ISG15 from ISGylated proteins. ISG15-specific protease activity of this enzyme is crucial for proper cellular balance of ISG15-conjugated proteins. However, it is not required for processing pre-ISG15 to the mature form. Furthermore, USP18 inhibits type I interferon signaling independent of its ISG15 deconjugating enzyme activity. Several viral proteins were also reported with de-ISGylation activity.
Literature References
PubMed ID Title Journal Year
11788588 UBP43 (USP18) specifically removes ISG15 from conjugated proteins

Malakhov, MP, Malakhova, OA, Kim, KI, Ritchie, KJ, Zhang, DE

J Biol Chem 2002
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Catalyst Activity

ISG15-specific peptidase activity of USP18 [cytosol]

Physical Entity
USP18 [cytosol] (Homo sapiens)
Activity
ISG15-specific peptidase activity (GO:0019785)
Orthologous Events
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Bos taurus)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Caenorhabditis elegans)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Canis familiaris)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Dictyostelium discoideum)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Mus musculus)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Rattus norvegicus)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Sus scrofa)
Authored
Garapati, P V  (2011-01-18)
Reviewed
Zhang, DE  (2011-02-11)
Created
Garapati, P V  (2011-10-19)
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