Internalization of Nef:CD28:Clathrin-Coated Pit Adapter Protein Complex

Stable Identifier
R-HSA-167637
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
Locations in the PathwayBrowser
General
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Once Nef has induced endocytosis of CD28, CD28 containing vesicles are targeted for lysosomal degradation.

Literature References
PubMed ID Title Journal Year
11285224 Mechanism for down-regulation of CD28 by Nef

Swigut, T, Shohdy, N, Skowronski, J

EMBO J 2001
Participants
Participant Of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created
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