Nef mediated downregulation of CD28 cell surface expression

Stable Identifier
R-HSA-164939
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
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Down-regulation of CD28 receptors involves a dileucine-based motif in the second disordered loop of Nef, which connects Nef to adaptor protein (AP) complex, which is a part of cellular endocytosis machinery. Nef induces accelerated endocytosis of CD28 via clathrin-coated pits followed by lysosomal degradation.

Literature References
PubMed ID Title Journal Year
11285224 Mechanism for down-regulation of CD28 by Nef

Swigut, T, Shohdy, N, Skowronski, J

EMBO J 2001
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Authored
Reviewed
Created
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