Nef mediated downregulation of CD28 cell surface expression

Stable Identifier
R-HSA-164939
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
ReviewStatus
5/5
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Nef mediated downregulation of CD28 cell surface expression
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Down-regulation of CD28 receptors involves a dileucine-based motif in the second disordered loop of Nef, which connects Nef to adaptor protein (AP) complex, which is a part of cellular endocytosis machinery. Nef induces accelerated endocytosis of CD28 via clathrin-coated pits followed by lysosomal degradation.
Literature References
PubMed ID Title Journal Year
11285224 Mechanism for down-regulation of CD28 by Nef

Shohdy, N, Swigut, T, Skowronski, J

EMBO J 2001
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
virus-mediated perturbation of host defense response (0019049)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Cross References
BioModels Database
Authored
Gillespie, ME  (2007-07-25)
Reviewed
Skowronski, J  (2007-08-07)
Created
Gillespie, ME  (2005-07-23)
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