Reactome | PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane

PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane

Stable Identifier

R-HSA-1676185

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

5/5

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PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane

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At the Golgi membrane, phosphatidylinositol 4-kinase alpha (PI4KA) (Gehrmann et al. 1999, Godi et al. 1999), or phosphatidylinositol 4-kinase type 2-alpha/beta (PI4K2A/B) (Balla et al. 2002, Minogue et al. 2001, Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).

Literature References

PubMed ID	Title	Journal	Year
11279162	Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family Waugh, MG, Anderson, JS, Minogue, S, dos Santos, M, Cramer, R, Hsuan, JJ, Corless, S	J Biol Chem	2001
12324459	Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP Wei, YJ, Barylko, B, Yamamoto, M, Albanesi, JP, Wlodarski, P, Sun, HQ, Martínez, M, Yin, HL, Kunii, K	J Biol Chem	2002
10101268	Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230 Balla, A, Gülkan, H, Herberg, FW, Gehrmann, T, Mayr, GW, Vereb, G, Heilmeyer LM, Jr, Suer, S	Biochim Biophys Acta	1999
10559940	ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex Corda, D, Luini, A, Di Tullio, G, Godi, A, Iurisci, C, Pertile, P, Meyers, R, De Matteis, MA, Marra, P	Nat Cell Biol	1999
11923287	Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments Balla, T, Tuymetova, G, Balla, A, Barshishat, M, Geiszt, M	J Biol Chem	2002