Reactome | PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane

PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane

Stable Identifier

R-HSA-1676185

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

ReviewStatus

5/5

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PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane

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At the Golgi membrane, phosphatidylinositol 4-kinase alpha (PI4KA) (Gehrmann et al. 1999, Godi et al. 1999), or phosphatidylinositol 4-kinase type 2-alpha/beta (PI4K2A/B) (Balla et al. 2002, Minogue et al. 2001, Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).

Literature References

PubMed ID	Title	Journal	Year
11279162	Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family Minogue, S, Anderson, JS, Waugh, MG, dos Santos, M, Corless, S, Cramer, R, Hsuan, JJ	J Biol Chem	2001
12324459	Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP Wei, YJ, Sun, HQ, Yamamoto, M, Wlodarski, P, Kunii, K, Martínez, M, Barylko, B, Albanesi, JP, Yin, HL	J Biol Chem	2002
10101268	Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230 Gehrmann, T, Gülkan, H, Suer, S, Herberg, FW, Balla, A, Vereb, G, Mayr, GW, Heilmeyer LM, Jr	Biochim Biophys Acta	1999
10559940	ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex Godi, A, Pertile, P, Meyers, R, Marra, P, Di Tullio, G, Iurisci, C, Luini, A, Corda, D, De Matteis, MA	Nat Cell Biol	1999
11923287	Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments Balla, A, Tuymetova, G, Barshishat, M, Geiszt, M, Balla, T	J Biol Chem	2002