PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane

Stable Identifier
R-HSA-1676185
Type
Reaction [transition]
Species
Homo sapiens
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At the Golgi membrane, phosphatidylinositol 4-kinase alpha (PI4KA) (Gehrmann et al. 1999, Godi et al. 1999), or phosphatidylinositol 4-kinase type 2-alpha/beta (PI4K2A/B) (Balla et al. 2002, Minogue et al. 2001, Wei et al. 2002) phosphorylate phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P).

Literature References
PubMed ID Title Journal Year
12324459 Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP

Wei, YJ, Sun, HQ, Yamamoto, M, Wlodarski, P, Kunii, K, Martínez, M, Barylko, B, Albanesi, JP, Yin, HL

J Biol Chem 2002
11279162 Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family

Minogue, S, Anderson, JS, Waugh, MG, dos Santos, M, Corless, S, Cramer, R, Hsuan, JJ

J Biol Chem 2001
10101268 Functional expression and characterisation of a new human phosphatidylinositol 4-kinase PI4K230

Gehrmann, T, Gülkan, H, Suer, S, Herberg, FW, Balla, A, Vereb, G, Mayr, GW, Heilmeyer LM, Jr

Biochim Biophys Acta 1999
10559940 ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex

Godi, A, Pertile, P, Meyers, R, Marra, P, Di Tullio, G, Iurisci, C, Luini, A, Corda, D, De Matteis, MA

Nat Cell Biol 1999
11923287 Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments

Balla, A, Tuymetova, G, Barshishat, M, Geiszt, M, Balla, T

J Biol Chem 2002
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Catalyst Activity
Title
1-phosphatidylinositol 4-kinase activity of PI4KA/2A/2B [cytosol]
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