Reactome | Synthesis of PIPs at the Golgi membrane

Synthesis of PIPs at the Golgi membrane

Stable Identifier

R-HSA-1660514

DOI

10.3180/R-HSA-1660514.4

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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At the Golgi membrane, phosphatidylinositol 4-phosphate (PI4P) is primarily generated from phosphorylation of phosphatidylinositol (PI). Other phosphoinositides are also generated by the action of various kinases and phosphatases such as: phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2), phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (Godi et al. 1999, Minogue et al. 2001, Rohde et al. 2003, Sbrissa et al. 2007, Sbrissa et al. 2008, Domin et al. 2000, Arcaro et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
11279162	Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family Minogue, S, Anderson, JS, Waugh, MG, dos Santos, M, Corless, S, Cramer, R, Hsuan, JJ	J Biol Chem	2001
10805725	Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors Arcaro, A, Zvelebil, MJ, Wallasch, C, Ullrich, A, Waterfield, MD, Domin, J	Mol Cell Biol	2000
10766823	The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles Domin, J, Gaidarov, I, Smith, ME, Keen, JH, Waterfield, MD	J Biol Chem	2000
17556371	Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex Sbrissa, D, Ikonomov, OC, Fu, Z, Ijuin, T, Gruenberg, J, Takenawa, T, Shisheva, A	J Biol Chem	2007
10559940	ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex Godi, A, Pertile, P, Meyers, R, Marra, P, Di Tullio, G, Iurisci, C, Luini, A, Corda, D, De Matteis, MA	Nat Cell Biol	1999
18950639	ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality Sbrissa, D, Ikonomov, OC, Fenner, H, Shisheva, A	J Mol Biol	2008
14527956	The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex Rohde, HM, Cheong, FY, Konrad, G, Paiha, K, Mayinger, P, Boehmelt, G	J Biol Chem	2003