At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) and beta (PIP4K2B) homodimers and heterodimers (Clarke et al. 2010), along with phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2).The following lists the above proteins with their corresponding literature references: PIP4K2A (Zhang et al. 1997, Rameh et al. 1997, Clarke et al. 2008), PIP4K2B (Zhang et al. 1997, Rameh et al. 1997), PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002).
Rameh, LE, Cantley, LC, Duckworth, BC, Tolias, KF
Thum, O, Majerus, PW, Parker, GJ, Boronenkov, IV, Zhang, X, Prestwich, GD, Anderson, RA, Loijens, JC, Chen, J, Norris, FA
Rameh, LE, Cantley, LC, Ishihara, H, Shibasaki, Y, Prestwich, GD, Carpenter, CL, Chen, J, Tolias, KF
Wang, M, Irvine, RF, Clarke, JH
Cestra, G, Pellegrini, L, Di Paolo, G, Zoncu, R, Letinic, K, Wenk, MR, Voronov, S, De Camilli, P, Guo, J, Chang, S
Irvine, RF, Emson, PC, Clarke, JH
Daniell, L, Di Paolo, G, Pellegrini, L, Arioka, M, Martin, TF, Wenk, MR, De Camilli, P, Chang, S, Klenchin, VA
1-phosphatidylinositol-3-phosphate 4-kinase activity of PIP4K2/5K1 [cytosol]
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