Reactome | PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane

PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane

Stable Identifier

R-HSA-1676145

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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PI3P is phosphorylated to PI(3,4)P2 by PIP4K2/5K1 at the plasma membrane

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At the plasma membrane, phosphatidylinositol-5-phosphate 4-kinase type-2 alpha (PIP4K2A) and beta (PIP4K2B) homodimers and heterodimers (Clarke et al. 2010), along with phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2).

The following lists the above proteins with their corresponding literature references: PIP4K2A (Zhang et al. 1997, Rameh et al. 1997, Clarke et al. 2008), PIP4K2B (Zhang et al. 1997, Rameh et al. 1997), PIP5K1A (Zhang et al. 1997, Tolias et al. 1998), PIP5K1B (Zhang et al. 1997, Tolias et al. 1998), and PIP5K1C (Wenk et al. 2001, Di Paolo et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
9367159	A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate Rameh, LE, Tolias, KF, Duckworth, BC, Cantley, LC	Nature	1997
9211928	Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules Zhang, X, Loijens, JC, Boronenkov, IV, Parker, GJ, Norris, FA, Chen, J, Thum, O, Prestwich, GD, Majerus, PW, Anderson, RA	J Biol Chem	1997
9660759	Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate Tolias, KF, Rameh, LE, Ishihara, H, Shibasaki, Y, Chen, J, Prestwich, GD, Cantley, LC, Carpenter, CL	J Biol Chem	1998
19896968	Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases Clarke, JH, Wang, M, Irvine, RF	Adv Enzyme Regul	2010
12422219	Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin Di Paolo, G, Pellegrini, L, Letinic, K, Cestra, G, Zoncu, R, Voronov, S, Chang, S, Guo, J, Wenk, MR, De Camilli, P	Nature	2002
18753295	Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron Clarke, JH, Emson, PC, Irvine, RF	Am J Physiol Renal Physiol	2008
11604140	PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse Wenk, MR, Pellegrini, L, Klenchin, VA, Di Paolo, G, Chang, S, Daniell, L, Arioka, M, Martin, TF, De Camilli, P	Neuron	2001