At the Golgi membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 is bound to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). This PIK3C3:PIK2R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P).The following lists the above proteins with their corresponding literature references: PIK3C3:PIK2R4 (Panaretou et al. 1997, Volinia et al. 1995) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).
Waterfield, MD, Dhand, R, Stein, R, MacDougall, LK, Vanhaesebroeck, B, Volinia, S, Zvelebil, MJ, Domin, J, Panaretou, C
Waterfield, MD, Arcaro, A, Wallasch, C, Ullrich, A, Zvelebil, MJ, Domin, J
Waterfield, MD, Domin, J, Panaretou, C, Cockcroft, S
Waterfield, MD, Gaidarov, I, Domin, J, Smith, ME, Keen, JH
1-phosphatidylinositol-3-kinase activity of PIK3C2A/3 [cytosol]
© 2023 Reactome
