PI is phosphorylated to PI4P by PI4KB at the Golgi membrane

Stable Identifier
R-HSA-1675883
Type
Reaction
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
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PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
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At the Golgi membrane, activated phosphatidylinositol 4-kinase beta (PI4KB) complexed to ADP-ribosylation factor 1/3 (ARF1/3) phosphorylates phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) (Suzuki et al. 1997).

Literature References
PubMed ID Title Journal Year
9405935 Identification and characterization of a novel human phosphatidylinositol 4-kinase

Suzuki, M, Suzuki, K, Horie, M, Kuga, Y, Hirano, H, Kanemoto, N, Okutomi, K, Fujiwara, T, Isono, K

DNA Res 1997
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Catalyst Activity

1-phosphatidylinositol 4-kinase activity of ARF1/3:GTP:PI4KB [Golgi membrane]

Physical Entity
ARF1/3:GTP:PI4KB [Golgi membrane] (Homo sapiens)
Activity
1-phosphatidylinositol 4-kinase activity (GO:0004430)
Orthologous Events
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Caenorhabditis elegans)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Canis familiaris)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Danio rerio)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Dictyostelium discoideum)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Drosophila melanogaster)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Gallus gallus)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Mus musculus)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Plasmodium falciparum)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Rattus norvegicus)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Saccharomyces cerevisiae)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Schizosaccharomyces pombe)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Sus scrofa)
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane (Xenopus tropicalis)
Authored
Williams, MG  (2011-10-18)
Reviewed
Wakelam, M  (2012-05-14)
Created
Williams, MG  (2011-10-17)
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