The high affinity receptor complex binds to G-protein

Stable Identifier
R-HSA-167408
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The high affinity complex beta-endorphin:mu opioid receptor binds to the heterotrimeric G-protein. This binding stabilises a conformation of the G-protein alpha i subunit presenting a low affinity for GDP, but a high affinity for GTP

Literature References
PubMed ID Title Journal Year
9544801 Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I

Burford, NT, Tolbert, LM, Sadee, W

Eur J Pharmacol 1998
16415903 Differential activation of G-proteins by mu-opioid receptor agonists

Saidak, Z, Blake-Palmer, K, Hay, DL, Northup, JK, Glass, M

Br J Pharmacol 2006
10215864 Nonselective coupling of the human mu-opioid receptor to multiple inhibitory G-protein isoforms

Gaibelet, G, Meilhoc, E, Riond, J, Saves, I, Exner, T, Liaubet, L, Nurnberg, B, Masson, JM, Emorine, LJ

Eur J Biochem 1999
11786497 Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells

Alt, A, Clark, MJ, Woods, JH, Traynor, JR

Br J Pharmacol 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
G protein-coupled receptor activity of Opioid:MOR [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created