Reactome | The high affinity receptor complex binds to G-protein

The high affinity receptor complex binds to G-protein

Stable Identifier

R-HSA-167408

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein activation (Homo sapiens)
        
        The high affinity receptor complex binds to G-protein (Homo sapiens)

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The high affinity receptor complex binds to G-protein

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The high affinity complex beta-endorphin:mu opioid receptor binds to the heterotrimeric G-protein. This binding stabilises a conformation of the G-protein alpha i subunit presenting a low affinity for GDP, but a high affinity for GTP

Literature References

PubMed ID	Title	Journal	Year
16415903	Differential activation of G-proteins by mu-opioid receptor agonists Saidak, Z, Blake-Palmer, K, Hay, DL, Northup, JK, Glass, M	Br J Pharmacol	2006
9544801	Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I Burford, NT, Tolbert, LM, Sadee, W	Eur J Pharmacol	1998
10215864	Nonselective coupling of the human mu-opioid receptor to multiple inhibitory G-protein isoforms Gaibelet, G, Meilhoc, E, Riond, J, Saves, I, Exner, T, Liaubet, L, Nurnberg, B, Masson, JM, Emorine, LJ	Eur J Biochem	1999
11786497	Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells Alt, A, Clark, MJ, Woods, JH, Traynor, JR	Br J Pharmacol	2002