The high affinity receptor complex binds to G-protein

Stable Identifier
Reaction [transition]
Homo sapiens
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The high affinity complex beta-endorphin:mu opioid receptor binds to the heterotrimeric G-protein. This binding stabilises a conformation of the G-protein alpha i subunit presenting a low affinity for GDP, but a high affinity for GTP

Literature References
PubMed ID Title Journal Year
16415903 Differential activation of G-proteins by mu-opioid receptor agonists

Glass, M, Saidak, Z, Blake-Palmer, K, Northup, JK, Hay, DL

Br J Pharmacol 2006
9544801 Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I

Burford, NT, Tolbert, LM, Sadee, W

Eur J Pharmacol 1998
10215864 Nonselective coupling of the human mu-opioid receptor to multiple inhibitory G-protein isoforms

Saves, I, Gaibelet, G, Exner, T, Emorine, LJ, Nurnberg, B, Masson, JM, Riond, J, Liaubet, L, Meilhoc, E

Eur J Biochem 1999
11786497 Mu and Delta opioid receptors activate the same G proteins in human neuroblastoma SH-SY5Y cells

Woods, JH, Clark, MJ, Alt, A, Traynor, JR

Br J Pharmacol 2002
Catalyst Activity

G protein-coupled receptor activity of Opioid:MOR [plasma membrane]

Orthologous Events
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