SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)

Stable Identifier
R-HSA-167153
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
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The capping enzyme interacts with the Spt5 subunit of transcription elongation factor DSIF. This interaction may couple the capping reaction with promoter escape or elongation, thereby acting as a "checkpoint" to assure that capping has occurred before the polymerase proceeds to make the rest of the transcript (Gonatopoulos-Pournatzis et al.2011).
Literature References
PubMed ID Title Journal Year
24354960 Cap-binding complex (CBC)

Gonatopoulos-Pournatzis, T, Cowling, VH

Biochem. J. 2014
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SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Matthews, L  (2005-07-27)
Rice, AP  (2005-07-27)
Created
Matthews, L  (2005-10-11)
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