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SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
Stable Identifier
R-HSA-167153
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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HIV Infection (Homo sapiens)
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Late Phase of HIV Life Cycle (Homo sapiens)
Transcription of the HIV genome (Homo sapiens)
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The capping enzyme interacts with the Spt5 subunit of transcription elongation factor DSIF. This interaction may couple the capping reaction with promoter escape or elongation, thereby acting as a "checkpoint" to assure that capping has occurred before the polymerase proceeds to make the rest of the transcript (Gonatopoulos-Pournatzis et al.2011).
Literature References
PubMed ID
Title
Journal
Year
24354960
Cap-binding complex (CBC)
Gonatopoulos-Pournatzis, T
,
Cowling, VH
Biochem. J.
2014
Participants
Input
p-SUPT5H [nucleoplasm]
(Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm]
(Homo sapiens)
RNMT [nucleoplasm]
(Homo sapiens)
Output
CE:Pol II CTD:Spt5 complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection (Homo sapiens)
Inferred From
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Matthews, L (2005-07-27)
Rice, AP (2005-07-27)
Created
Matthews, L (2005-10-11)
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