2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing

Stable Identifier
R-HSA-167076
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
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Pol II pausing is believed to result from reversible backtracking of the Pol II enzyme complex by ~2 to 4 nucleotides. This leads to misaligned 3'-OH terminus that is unable to be an acceptor for the incoming NTPs in synthesis of next phosphodiester bond (reviewed by Shilatifard et al., 2003).
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Inferred From
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Homo sapiens)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Matthews, L  (2005-07-27)
Rice, AP  (2005-07-27)
Created
Matthews, L  (2005-10-11)
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