Reactome | 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing

2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing

Stable Identifier

R-HSA-167076

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

nucleoplasm

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Transcription of the HIV genome (Homo sapiens)
        
        Pausing and recovery of Tat-mediated HIV elongation (Homo sapiens)
        
        2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)

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2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing

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Pol II pausing is believed to result from reversible backtracking of the Pol II enzyme complex by ~2 to 4 nucleotides. This leads to misaligned 3'-OH terminus that is unable to be an acceptor for the incoming NTPs in synthesis of next phosphodiester bond (reviewed by Shilatifard et al., 2003).

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