2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing

Stable Identifier
R-HSA-113411
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
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Pol II pausing is believed to result from reversible backtracking of the Pol II enzyme complex by ~2 to 4 nucleotides. This leads to misaligned 3'-OH terminus that is unable to be an acceptor for the incoming NTPs in synthesis of next phosphodiester bond (reviewed by Shilatifard et al., 2003).

Literature References
PubMed ID Title Journal Year
12676794 The RNA polymerase II elongation complex.

Conaway, JW, Shilatifard, A, Conaway, RC

Annu Rev Biochem 2003
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Orthologous Events
2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing (Homo sapiens)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Bos taurus)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Caenorhabditis elegans)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Canis familiaris)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Danio rerio)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Drosophila melanogaster)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Gallus gallus)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Mus musculus)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Rattus norvegicus)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Schizosaccharomyces pombe)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Sus scrofa)
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Xenopus tropicalis)
Authored
Gopinathrao, G  (2004-06-23)
Created
Conaway, JW  (2003-09-11)
Conaway, RC  (2003-09-11)
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