TRAF6 binds MEKK1

Stable Identifier
R-HSA-166869
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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TRAF6 binds MEKK1
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TRAF6 binding to MAPK kinase kinase 1 (MEKK1) is mediated by the adapter protein evolutionarily conserved signaling intermediate in Toll pathway or in short ECSIT (Kopp E et al 1999). Induced MEKK1 can activate both IKK alpha and IKK beta thus leading to induction of NF-kappa-B activation. MEKK1 was also shown to induce ERK1/2 and JNK activation [Yujiri T et al 1998].

Although TRAF6 interacts with several upstream mediators (IRAK1, IRAK2, TRIF), there is no data showing MEKK1 participating in the interaction with the TRAF6 activators. Therefore this reaction is simplified to include only TRAF6 and MEKK1.

Literature References
PubMed ID Title Journal Year
10465784 ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

Kopp, E, Carothers, J, Ghosh, S, Xiao, C, Douglas, I, Janeway, CA, Medzhitov, R

Genes Dev 1999
9008162 Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

Lee, FS, Hagler, J, Chen, ZJ, Maniatis, T

Cell 1997
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This event is regulated
Requirements
Orthologous Events
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Authored
de Bono, B  (2005-08-16)
Reviewed
Gillespie, ME  (2010-11-30)
Gay, NJ  (2006-04-24)
Napetschnig, J  (2012-11-16)
Created
de Bono, B  (2005-09-21)
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