Reactome | MASP2-1(16-444) [extracellular region]

MASP2-1(16-444) [extracellular region]

Stable Identifier

R-HSA-166705

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

MASP2 A chain, MASP2-1 isoform 1 A chain

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:activate MASP2-1 dimer:Ca2+ [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:activate MASP2-1 dimer:Ca2+ [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        Activation of MASPs (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        Ficolin-1:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        Ficolin-2:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        Ficolin-3:activated MASP-1:activated MASP-2:Ca2+:ficolin ligand [plasma membrane] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)
        
        S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:MBL2 dodecamer:MASP1 dimer:activate MASP2-1 dimer:Ca2+ [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        Activated MASP2-1 [extracellular region] (Homo sapiens)
        
        MASP2-1(16-444) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00187-1 MASP2

Gene Names

MASP2

Participates

as a component of

Activated MASP2-1 [extracellular region] (Homo sapiens)

Other forms of this molecule

MASP2-1 [extracellular region]

MASP2-1(445-686) [extracellular region]

Cross References

RefSeq

NP_631947.1, NP_006601.2

ENSEMBL

ENST00000400897, ENST00000400898, ENSP00000383690, ENSP00000383691, ENSG00000009724

OpenTargets

ENSG00000009724

IntEnz

3.4.21.104

GeneCards

MASP2

HPA

ENSG00000009724-MASP2

PRO

O00187

Pharos - Targets

O00187

GlyGen

O00187

Orphanet

MASP2

HMDB Protein

HMDBP07788

PDB

9D4D, 1Q3X, 9D40, 9D3Y, 9D17, 1SZB, 1ZJK, 5JPM, 3TVJ, 7PQN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
mannan [ChEBI:28808]	1	alpha-mannan [plasma membrane] (R-ALL-5621136)	0.75	4
UniProt:P05155 SERPING1	20	SERPING1 L177P [endoplasmic reticulum lumen] (R-HSA-9650574) SERPING1 R400C [endoplasmic reticulum lumen] (R-HSA-9650511) SERPING1 V288E [endoplasmic reticulum lumen] (R-HSA-9650415) SERPING1 G184_P228del [endoplasmic reticulum lumen] (R-HSA-9650472) SERPING1 F236S [endoplasmic reticulum lumen] (R-HSA-9650538) SERPING1 T189N [endoplasmic reticulum lumen] (R-HSA-9650346) SERPING1 P476L [endoplasmic reticulum lumen] (R-HSA-9650563) SERPING1 G184R [endoplasmic reticulum lumen] (R-HSA-9650424) SERPING1 P489R [endoplasmic reticulum lumen] (R-HSA-9650330) SERPING1 S170P [endoplasmic reticulum lumen] (R-HSA-9650362) SERPING1 S280_P282del [endoplasmic reticulum lumen] (R-HSA-9650522) SERPING1 V473M [endoplasmic reticulum lumen] (R-HSA-9650331) SERPING1 N291H [endoplasmic reticulum lumen] (R-HSA-9650545) SERPING1 Q484* [endoplasmic reticulum lumen] (R-HSA-9650410) SERPING1 A2_M53del [endoplasmic reticulum lumen] (R-HSA-9651435) SERPING1 W482* [endoplasmic reticulum lumen] (R-HSA-9650502) SERPING1 Q338* [endoplasmic reticulum lumen] (R-HSA-9651424) SERPING1 I196N [endoplasmic reticulum lumen] (R-HSA-9651390) SERPING1 S36Ffs*21 [endoplasmic reticulum lumen] (R-HSA-9651423) SERPING1 G184E [endoplasmic reticulum lumen] (R-HSA-9650527)	0.676	3