TRAF6 binds to hp- IRAK1

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Chlamydia trachomatis, Neisseria meningitidis serogroup B
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Hyperphosphorylated IRAK1, still within the receptor complex, binds TRAF6 through multiple regions including the death domain, the undefined domain and the C-terminal C1 domain (Li et al. 2001). The C-terminal region of IRAK-1 contains three potential TRAF6-binding sites; mutation of the amino acids (Glu544, Glu587, Glu706) in these sites to alanine greatly reduces activation of NFkappaB (Ye et al. 2002).
Literature References
PubMed ID Title Journal Year
12138165 Identification of threonine 66 as a functionally critical residue of the

Dower, S, Volpe, F, Ross, K, Guesdon, F, Yang, L

J Biol Chem 2002
8837778 TRAF6 is a signal transducer for interleukin-1

Cao, Z, Kurama, T, Xiong, J, Takeuchi, M, Goeddel, DV

Nature 1996
18070982 TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB

Muroi, M, Tanamoto, K

J Leukoc Biol 2008
12140561 Distinct molecular mechanism for initiating TRAF6 signalling

Vologodskaia, M, Kobayashi, T, Wu, H, Cirilli, M, Lamothe, B, Arron, JR, Pike, JW, Ye, H, Shevde, NK, Choi, Y, Yim, M, Darnay, BG, Du, K, Dzivenu, OK, Segal, D, Singh, S

Nature 2002
Orthologous Events
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