Reactome | TRAF6 binds to p-IRAK2 complexed with activated TLR

TRAF6 binds to p-IRAK2 complexed with activated TLR

Stable Identifier

R-GGA-434053

Type

Reaction [binding]

Species

Gallus gallus

Related Species

Salmonella typhimurium

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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TRAF6 binds to p-IRAK2 complexed with activated TLR

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There is little experimental data about mammalian IRAK2 mediated signaling. It is possible that phosphorylated IRAK2, like IRAK1, dissociates from upstream adapters such as MyD88 but leaves its interaction with the downstream adapter TRAF6 unaffected. Furthermore Keating et al. [2007] showed that IRAK2 can promote TRAF6 ubiquitination. Other studies [Wan et al 2009] detected IRAK2-TRAF6 interaction upon LPS stimulation.

In this reaction we assume that chicken IRAK2 behaves like its mammalian homolog IRAK2.

Literature References

PubMed ID	Title	Journal	Year
17878161	IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination Keating, SE, Maloney, GM, Moran, EM, Bowie, AG	J Biol Chem	2007
18070982	TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-kappaB Muroi, M, Tanamoto, K	J Leukoc Biol	2008
19224918	Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control Wan, Y, Xiao, H, Affolter, J, Kim, TW, Bulek, K, Chaudhuri, S, Carlson, D, Hamilton, T, Mazumder, B, Stark, GR, Thomas, J, Li, X	J Biol Chem	2009