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Expression of Lanosterol Demethylase (CYP51A1)
Stable Identifier
R-HSA-1655847
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
,
endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Lanosterol Demethylase (CYP51A1) (Homo sapiens)
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The CYP51A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein. SREBF1A (SREBP1A) and SREBF2 (SREBP2) bind the promoter of the Lanosterol Demethylase (CYP51A1) gene and enhance transcription (Pai et al. 1998, Sakakura et al. 2001, Halder et al. 2002, Reed et al. 2008, reviewed in Horton et al. 2002).
Literature References
PubMed ID
Title
Journal
Year
8619637
The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols
Stromstedt, M
,
Waterman, MR
,
Rozman, D
Arch Biochem Biophys
1996
Participants
Input
CYP51A1 gene [nucleoplasm]
(Homo sapiens)
Output
CYP51A1 [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an event of
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
This event is regulated
Positively by
Regulator
SREBP1A,2:NF-Y:SP1:CYP51A1 gene [nucleoplasm]
(Homo sapiens)
Authored
May, B (2011-09-28)
Reviewed
Liang, G (2012-08-26)
Created
May, B (2011-10-13)
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