S1P hydrolyzes SREBP1A,1C,2

Stable Identifier
R-HSA-1655842
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
SKI-1 hydrolyzes SREBP1A,1C,2, S1P hydrolyzes SREBF1A,1C,2
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S1P (MBTPS1, SKI-1), a membrane-bound protease in the Golgi, cleaves the intralumenal loop of SREBP1A/1C/2 (SREBF1A/1C/2), releasing the N-terminal domain of SREBP1A/1C/2, which remains bound to the membrane.

Literature References
PubMed ID Title Journal Year
9488713 Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

Sakai, J, Nohturfft, A, Goldstein, JL, Brown, MS

J Biol Chem 1998
8674110 Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

Sakai, J, Duncan, EA, Rawson, RB, Hua, X, Brown, MS, Goldstein, JL

Cell 1996
8156598 SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Wang, X, Sato, R, Brown, MS, Hua, X, Goldstein, JL

Cell 1994
10644685 Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment

Touré, BB, Munzer, JS, Basak, A, Benjannet, S, Rochemont, J, Lazure, C, Chretien, M, Seidah, NG

J Biol Chem 2000
10428864 Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

Espenshade, PJ, Cheng, D, Goldstein, JL, Brown, MS

J Biol Chem 1999
17449569 Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells

Shin, ES, Lee, HH, Cho, SY, Park, HW, Lee, SJ, Lee, TR

J Nutr 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MBTPS1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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