S1P hydrolyzes SREBP1A,1C,2

Stable Identifier
R-HSA-1655842
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
SKI-1 hydrolyzes SREBP1A,1C,2, S1P hydrolyzes SREBF1A,1C,2
ReviewStatus
5/5
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S1P hydrolyzes SREBP1A,1C,2
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
S1P (MBTPS1, SKI-1), a membrane-bound protease in the Golgi, cleaves the intralumenal loop of SREBP1A/1C/2 (SREBF1A/1C/2), releasing the N-terminal domain of SREBP1A/1C/2, which remains bound to the membrane.
Literature References
PubMed ID Title Journal Year
8674110 Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

Brown, MS, Rawson, RB, Hua, X, Duncan, EA, Sakai, J, Goldstein, JL

Cell 1996
9488713 Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

Brown, MS, Nohturfft, A, Sakai, J, Goldstein, JL

J Biol Chem 1998
8156598 SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Brown, MS, Wang, X, Goldstein, JL, Hua, X, Sato, R

Cell 1994
10644685 Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment

Lazure, C, Seidah, NG, Rochemont, J, Chretien, M, Touré, BB, Benjannet, S, Munzer, JS, Basak, A

J Biol Chem 2000
10428864 Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

Brown, MS, Cheng, D, Espenshade, PJ, Goldstein, JL

J Biol Chem 1999
17449569 Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells

Shin, ES, Lee, HH, Park, HW, Lee, TR, Cho, SY, Lee, SJ

J Nutr 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of MBTPS1 [Golgi membrane]

Physical Entity
MBTPS1 [Golgi membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
S1P hydrolyzes SREBP1A,1C,2 (Bos taurus)
S1P hydrolyzes SREBP1A,1C,2 (Canis familiaris)
S1P hydrolyzes SREBP1A,1C,2 (Drosophila melanogaster)
S1P hydrolyzes SREBP1A,1C,2 (Gallus gallus)
S1P hydrolyzes SREBP1A,1C,2 (Mus musculus)
S1P hydrolyzes SREBP1A,1C,2 (Rattus norvegicus)
S1P hydrolyzes SREBP1A,1C,2 (Sus scrofa)
S1P hydrolyzes SREBP1A,1C,2 (Xenopus tropicalis)
Authored
May, B  (2011-09-28)
Reviewed
Liang, G  (2012-08-26)
Created
May, B  (2011-10-13)
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