S1P hydrolyzes SREBP1A,1C,2

Stable Identifier
Reaction [transition]
Homo sapiens
SKI-1 hydrolyzes SREBP1A,1C,2, S1P hydrolyzes SREBF1A,1C,2
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S1P (MBTPS1, SKI-1), a membrane-bound protease in the Golgi, cleaves the intralumenal loop of SREBP1A/1C/2 (SREBF1A/1C/2), releasing the N-terminal domain of SREBP1A/1C/2, which remains bound to the membrane.
Literature References
PubMed ID Title Journal Year
8674110 Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

Brown, MS, Rawson, RB, Hua, X, Duncan, EA, Sakai, J, Goldstein, JL

Cell 1996
9488713 Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

Brown, MS, Nohturfft, A, Sakai, J, Goldstein, JL

J Biol Chem 1998
8156598 SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Brown, MS, Wang, X, Goldstein, JL, Hua, X, Sato, R

Cell 1994
10644685 Biosynthesis and enzymatic characterization of human SKI-1/S1P and the processing of its inhibitory prosegment

Lazure, C, Seidah, NG, Rochemont, J, Chretien, M, Touré, BB, Benjannet, S, Munzer, JS, Basak, A

J Biol Chem 2000
10428864 Autocatalytic processing of site-1 protease removes propeptide and permits cleavage of sterol regulatory element-binding proteins

Brown, MS, Cheng, D, Espenshade, PJ, Goldstein, JL

J Biol Chem 1999
17449569 Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells

Shin, ES, Lee, HH, Park, HW, Lee, TR, Cho, SY, Lee, SJ

J Nutr 2007
Catalyst Activity

serine-type endopeptidase activity of MBTPS1 [Golgi membrane]

Orthologous Events
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