Conformational change in gp120 of Env oligomer

Stable Identifier
R-HSA-164510
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Conformational change in gp120 of Env oligomer
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
HIV-1 infection of target cells depends on the sequential interaction of the gp120 glycoprotein with the cellular CD4 receptor as well as members of the chemokine receptor family, such as CCR5. Upon interaction with the cellular CD4 receptor, gp120 undergoes a conformation change which allows interaction with these chemokine receptors to occur. Studies indicate that upon binding to CD4, this conformational change results in a repositioning of V1 and V2 loops of gp120, and exposes or forms the "bridging sheet domain" epitopes, which are then available for co-receptor (chemokine receptor) binding along with other domains of gp120. These epitopes are recognized by 17b, a member of a class of antibodies that recognize CD4-induced (CD4i) epitopes (Kwong et al., 1998, Rizzuto et al., 1998, Zhang et al., 1999).
Literature References
PubMed ID Title Journal Year
2441877 Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor

Capon, DJ, Gregory, T, Berman, P, Shimasaki, C, Fennie, C, Lasky, LA, Patzer, E, Nakamura, G, Smith, DH

Cell 1987
9641677 Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

Sodroski, J, Hendrickson, WA, Sweet, RW, Robinson, J, Wyatt, R, Kwong, PD

Nature 1998
10413516 Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic

Sodroski, J, Chaiken, I, Canziani, G, Zhang, W, Hendrickson, W, Sweet, R, Wyatt, R, Kwong, P, Plugariu, C

Biochemistry 1999
3629244 Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1

Sodroski, J, Potz, J, Dayton, A, Goh, WC, Basiripour, L, Kowalski, M, Rosen, C, Dorfman, T, Terwilliger, E

Science 1987
9573233 CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization

Sodroski, J, Thali, M, Sun, Y, Robinson, J, Gershoni, J, Sullivan, N, Moore, J, Wu, D, Denisova, G, Sattentau, Q

J Virol 1998
7687306 Characterization of neutralizing monoclonal antibodies to linear and conformation-dependent epitopes within the first and second variable domains of human immunodeficiency virus type 1 gp120

Bolmstedt, A, Page, M, Charles, M, Sullivan, N, Olofsson, S, Graham, S, Shotton, C, McKeating, JA, Balfe, P, Cordell, J

J Virol 1993
9632396 A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding

Sodroski, J, Hendrickson, WA, Rizzuto, CD, Sun, Y, Hernandez-Ramos, N, Kwong, PD, Wyatt, R

Science 1998
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
Bukrinsky, M  (2006-03-08)
Morrow, MP  (2006-03-08)
Reviewed
Reeves, J  (2006-06-12)
Created
D'Eustachio, P  (2005-05-24)
Cite Us!