First strand transfer mediated by Repeated (R) sequence

Stable Identifier
R-HSA-164503
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
cytosol
ReviewStatus
5/5
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First strand transfer mediated by Repeated (R) sequence
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The minus strand strong stop DNA (-sssDNA) is transferred to the 3' end of the HIV-1 genomic RNA, where the 3' end of the -sssDNA anneals to the viral genomic R sequence motif (Ghosh et al. 1995; Klaver and Berkhout 1994; Ohi and Clever 2000; Telesnitsky and Goff 1997). Viral NC (nucleocapsid) protein may play a role in this transfer (Driscoll and Hughes 2000).
Literature References
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Authored
D'Eustachio, P  (2006-05-19)
Gopinathrao, G  (2006-05-19)
Reviewed
Hughes, SH  (2006-10-31)
Created
D'Eustachio, P  (2005-05-24)
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