Reactome | SERPINA5 [extracellular region]

SERPINA5 [extracellular region]

Stable Identifier

R-HSA-5591085

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Plasma serine protease inhibitor, IPSP_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P05154 SERPINA5

Gene Names

SERPINA5, PCI, PLANH3, PROCI

Chain

signal peptide:1-19, propeptide:20-25, chain:26-406

Reference Genes

BioGPS Gene:5104 SERPINA5

COSMIC (genes):SERPINA5 SERPINA5

CTD Gene:5104 SERPINA5

dbSNP Gene:5104 SERPINA5

ENSEMBL:ENSG00000188488 SERPINA5

HGNC:8723 SERPINA5

KEGG:hsa:5104 SERPINA5

Monarch:5104 SERPINA5

NCBI Gene:5104 SERPINA5

OMIM:601841 SERPINA5

UCSC:P05154 SERPINA5

Reference Transcript

RefSeq:NM_000624.5 SERPINA5

Other Identifiers

11716376_at

16787878

16787880

16787882

209443_PM_at

209443_at

3549715

3549739

3549741

3549742

3549743

3549744

3549745

3549746

3549747

3549748

3549749

3549750

3549751

3549752

3549753

3549754

3549755

3549756

37008_r_at

5104

7976488

A_14_P139030

A_23_P205355

A_24_P321766

GE58046

GE80930

GO:0001972

GO:0002020

GO:0002080

GO:0004867

GO:0005515

GO:0005539

GO:0005576

GO:0005615

GO:0006869

GO:0007283

GO:0007338

GO:0007342

GO:0008201

GO:0008289

GO:0009897

GO:0016020

GO:0022414

GO:0030312

GO:0031012

GO:0031091

GO:0031094

GO:0031210

GO:0031410

GO:0032190

GO:0032991

GO:0036024

GO:0036025

GO:0036026

GO:0036027

GO:0036028

GO:0036029

GO:0036030

GO:0043226

GO:0051346

GO:0061024

GO:0062023

GO:0070062

GO:0097181

GO:0097182

GO:0097183

GO:0098772

HMNXSV003037154

ILMN_1759910

M68516_rna1_at

PH_hs_0004406

TC14002308.hg

g180549_3p_at

Participates

as a component of

SERPINA5:Activated protein C [extracellular region] (Homo sapiens)

as an input of

SERPINA5 binds activated protein C (Homo sapiens)

Inferred To

SERPINA5 [extracellular region] (Bos taurus)

SERPINA5 [extracellular region] (Caenorhabditis elegans)

SERPINA5 [extracellular region] (Canis familiaris)

SERPINA5 [extracellular region] (Sus scrofa)

Spn42Da [extracellular region] (Drosophila melanogaster)

srp-6 [extracellular region] (Caenorhabditis elegans)

Spn28Da [extracellular region] (Drosophila melanogaster)

Spn88Eb [extracellular region] (Drosophila melanogaster)

Spn27A [extracellular region] (Drosophila melanogaster)

srp-2 [extracellular region] (Caenorhabditis elegans)

Acp76A [extracellular region] (Drosophila melanogaster)

Spn100A [extracellular region] (Drosophila melanogaster)

Spn42Dd [extracellular region] (Drosophila melanogaster)

srp-8 [extracellular region] (Caenorhabditis elegans)

Spn43Aa [extracellular region] (Drosophila melanogaster)

Spn47C [extracellular region] (Drosophila melanogaster)

Dmel\CG43366 [extracellular region] (Drosophila melanogaster)

srp-7 [extracellular region] (Caenorhabditis elegans)

Spn42Db [extracellular region] (Drosophila melanogaster)

Spn75F [extracellular region] (Drosophila melanogaster)

Spn28Db [extracellular region] (Drosophila melanogaster)

Spn55B [extracellular region] (Drosophila melanogaster)

nec [extracellular region] (Drosophila melanogaster)

Spn31A [extracellular region] (Drosophila melanogaster)

Spn43Ab [extracellular region] (Drosophila melanogaster)

Spn53F [extracellular region] (Drosophila melanogaster)

Homologues of SERPINA5 [extracellular region] (Caenorhabditis elegans)

Homologues of SERPINA5 [extracellular region] (Drosophila melanogaster)

Homologues of SERPINA5 [extracellular region] (Xenopus tropicalis)

Spn88Ea [extracellular region] (Drosophila melanogaster)

serpina3m [extracellular region] (Xenopus tropicalis)

srp-1 [extracellular region] (Caenorhabditis elegans)

Serpina5 [extracellular region] (Mus musculus)

Serpina5 [extracellular region] (Rattus norvegicus)

Spn38F [extracellular region] (Drosophila melanogaster)

srp-3 [extracellular region] (Caenorhabditis elegans)

Spn42Dc [extracellular region] (Drosophila melanogaster)

Spn42De [extracellular region] (Drosophila melanogaster)

serpina3 [extracellular region] (Xenopus tropicalis)

si:ch211-186e20.7 [extracellular region] (Danio rerio)

Spn28B [extracellular region] (Drosophila melanogaster)

Spn85F [extracellular region] (Drosophila melanogaster)

Spn28F [extracellular region] (Drosophila melanogaster)

Spn43Ad [extracellular region] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSP00000450837, ENST00000554276, ENST00000553780, ENST00000329597, ENSP00000333203, ENSP00000451610, ENSP00000451126, ENST00000554866, ENSG00000188488

OpenTargets

ENSG00000188488

GeneCards

SERPINA5

HPA

ENSG00000188488-SERPINA5

PRO

P05154

Pharos - Targets

P05154

GlyGen

P05154

PDB

2HI9, 1LQ8, 2OL2, 3DY0

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02751 FN1	10	FN1(32-2477) [extracellular region] (R-HSA-54851) FN1(32-2477) [platelet alpha granule lumen] (R-HSA-114620) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935)	0.544	3
UniProt:O43149 ZZEF1			0.527	2
UniProt:Q5T447 HECTD3	1	HECTD3 [cytosol] (R-HSA-975991)	0.527	2
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.527	2
UniProt:Q04756 HGFAC	2	HGFAC(408-655) [cytosol] (R-HSA-6800283) HGFAC(373-407) [cytosol] (R-HSA-1641473)	0.527	2
UniProt:P09958 FURIN	6	FURIN [Golgi membrane] (R-HSA-157049) FURIN [extracellular region] (R-HSA-1181103) FURIN [plasma membrane] (R-HSA-2159856) FURIN [Golgi lumen] (R-HSA-448351) FURIN [trans-Golgi network membrane] (R-HSA-9832627) FURIN [macropinosome membrane] (R-HSA-9837714)	0.527	2

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