Reactome | Transcriptional activation of PKLR gene by ChREBP:MLX

Transcriptional activation of PKLR gene by ChREBP:MLX

Stable Identifier

R-HSA-163669

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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Transcriptional activation of PKLR gene by ChREBP:MLX

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The PKLR (pyruvate kinase) gene, activated by binding of MLXIPL:MLX (ChREBP:MLX) to its promoter region, is transcribed and the resulting mRNA is translated to yield PKLR protein (Ma et al. 2005, 2006, 2007). Additional regulatory effects of polyunsaturated fatty acids on PKLR gene expression suggested by studies of animal models (Dentin et al. 2005; Xu et al. 2006) have not been annotated here.

Literature References

PubMed ID	Title	Journal	Year
16184193	Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation Dentin, R, Benhamed, F, Pégorier, JP, Foufelle, F, Viollet, B, Vaulont, S, Girard, J, Postic, C	J Clin Invest	2005
16644726	Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist Xu, J, Christian, B, Jump, DB	J Biol Chem	2006
17148476	A critical role for the loop region of the basic helix-loop-helix/leucine zipper protein Mlx in DNA binding and glucose-regulated transcription Ma, L, Sham, YY, Walters, KJ, Towle, HC	Nucleic Acids Res.	2007
16885160	ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver Ma, L, Robinson, LN, Towle, HC	J. Biol. Chem.	2006
15664996	Direct role of ChREBP.Mlx in regulating hepatic glucose-responsive genes. Ma, L, Tsatsos, NG, Towle, HC	J Biol Chem	2005