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PKLR-1 [cytosol]
Stable Identifier
R-HSA-70097
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PKLR isozyme R, PKLR isoform 1, Pyruvate kinase, R isozyme, pyruvate kinase, liver and RBC, Red cell/liver pyruvate kinase
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
PKM dephosphorylates PEP to PYR (Homo sapiens)
pyruvate kinase tetramer [cytosol] (Homo sapiens)
pyruvate kinase complex, liver and RBC [cytosol] (Homo sapiens)
Pyruvate kinase, R/L type [cytosol] (Homo sapiens)
PKLR-1 [cytosol] (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
ChREBP activates metabolic gene expression (Homo sapiens)
Transcriptional activation of PKLR gene by ChREBP:MLX (Homo sapiens)
PKLR-1 [cytosol] (Homo sapiens)
Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
PKM dephosphorylates PEP to PYR (Homo sapiens)
pyruvate kinase tetramer [cytosol] (Homo sapiens)
pyruvate kinase complex, liver and RBC [cytosol] (Homo sapiens)
Pyruvate kinase, R/L type [cytosol] (Homo sapiens)
PKLR-1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30613-1 PKLR
Gene Names
PKLR, PK1, PKL
Participates
as an output of
Transcriptional activation of PKLR gene by ChREBP:MLX (Homo sapiens)
as a member of
Pyruvate kinase, R/L type [cytosol] (Homo sapiens)
Inferred To
PKLR-2 [cytosol]
(Canis familiaris)
PKLR-2 [cytosol]
(Dictyostelium discoideum)
PKLR-2 [cytosol]
(Drosophila melanogaster)
PKLR-2 [cytosol]
(Mus musculus)
PKLR-2 [cytosol]
(Plasmodium falciparum)
PKLR-2 [cytosol]
(Rattus norvegicus)
PKLR-2 [cytosol]
(Saccharomyces cerevisiae)
PKLR-2 [cytosol]
(Schizosaccharomyces pombe)
PKLR [cytosol]
(Bos taurus)
PKLR [cytosol]
(Sus scrofa)
pkma [cytosol]
(Danio rerio)
pyk-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_000289.1
,
NP_870986.1
Guide to Pharmacology - Targets
3007
OpenTargets
ENSG00000143627
ENSEMBL
ENSP00000461487
,
ENST00000342741
,
ENSP00000376214
,
ENSG00000262785
,
ENST00000392414
,
ENSG00000143627
,
ENST00000571194
,
ENSP00000339933
,
ENSP00000459921
,
ENST00000572740
ZINC - Substances
KPYR_HUMAN
ZINC target
P30613
PRO
P30613
GlyGen
P30613
PDB
5SCD
,
2VGI
,
7FRY
,
7FRW
,
8TBU
,
7FSB
,
2VGF
,
5SC8
,
5SCB
,
7FRX
,
7FS1
,
7FSA
,
8TBT
,
6NN5
,
7FS4
,
4IMA
,
7FRV
,
6NN8
,
2VGB
,
6NN7
,
5SCL
,
5SCH
,
5SCJ
,
5SCF
,
5SCC
,
5SDT
,
7FSC
,
5SC9
,
7FS2
,
8TBS
,
7FS9
,
2VGG
,
5SCA
,
7FS3
,
7FRZ
,
6NN4
,
7FS0
,
7FS8
,
7FS6
,
7FS7
,
7FS5
,
7FSD
,
7QDN
,
7QZU
,
4IP7
,
5SCK
,
8XFD
,
5SCG
,
5SCI
,
5SCE
HPA
ENSG00000143627-PKLR
GeneCards
PKLR
Pharos - Targets
P30613
Orphanet
PKLR
HMDB Protein
HMDBP00765
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