SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane

Stable Identifier
R-HSA-163215
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix
ReviewStatus
5/5
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SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane
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A family of antiport, ATP-ADP translocases (SLC25A4,5,6), preferentially export ATP from the matrix while importing ADP from the cytosol, thereby maintaining a high ADP:ATP ratio in the matrix. When there are increased energy demands on the body, such as under heavy exercise, cytosolic ADP rises and is exchanged with mitochondrial matrix ATP via the transmembrane ADP:ATP translocase. Increased ADP causes the proton-motive force to be discharged and protons enter via ATPase, thereby regenerating the ATP pool.
There are 3 isoforms of translocases in humans; isoform 1 (SLC25A4) is the heart/skeletal muscle form, isoform 2 (SLC25A5) is the fibroblast form and isoform 3 (SLC25A6) is the liver form. All isoforms exist as homodimers.
Literature References
PubMed ID Title Journal Year
5840415 Unspecific permeation and specific exchange of adenine nucleotides in

Pfaff, E, Klingenberg, M, Heldt, HW

Biochim Biophys Acta 1965
9587671 The mitochondrial ADP/ATP carrier: structural, physiological and

Fiore, C, Trezeguet, V, Le Saux, A, Roux, P, Schwimmer, C, Dianoux, AC, Noel, F, Lauquin, GJ, Brandolin, G, Vignais, PV

Biochimie 1998
5857365 [Exchange between extra- and intramitochondrial adenine nucleotides]

Duee, ED, Vignais, PV

Biochim Biophys Acta 1965
2648994 Molecular aspects of the adenine nucleotide carrier from mitochondria

Klingenberg, M

Arch Biochem Biophys 1989
Participants
Input
Output
Participates
as an event of
Catalyst Activity

adenine transmembrane transporter activity of SLC25A5,6 dimers [mitochondrial inner membrane]

Physical Entity
SLC25A5,6 dimers [mitochondrial inner membrane] (Homo sapiens)
Activity
adenine transmembrane transporter activity (GO:0015207)
Orthologous Events
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Bos taurus)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Caenorhabditis elegans)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Canis familiaris)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Danio rerio)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Dictyostelium discoideum)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Drosophila melanogaster)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Gallus gallus)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Mus musculus)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Plasmodium falciparum)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Rattus norvegicus)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Saccharomyces cerevisiae)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Schizosaccharomyces pombe)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Sus scrofa)
SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2005-06-30)
Created
Jassal, B  (2005-04-25)
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