SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane

Stable Identifier
Reaction [transition]
Homo sapiens
ADP-ATP translocase maintains a high ADP:ATP ratio in the matrix
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A family of antiport, ATP-ADP translocases (SLC25A4,5,6), preferentially export ATP from the matrix while importing ADP from the cytosol, thereby maintaining a high ADP:ATP ratio in the matrix. When there are increased energy demands on the body, such as under heavy exercise, cytosolic ADP rises and is exchanged with mitochondrial matrix ATP via the transmembrane ADP:ATP translocase. Increased ADP causes the proton-motive force to be discharged and protons enter via ATPase, thereby regenerating the ATP pool.
There are 3 isoforms of translocases in humans; isoform 1 (SLC25A4) is the heart/skeletal muscle form, isoform 2 (SLC25A5) is the fibroblast form and isoform 3 (SLC25A6) is the liver form. All isoforms exist as homodimers.
Literature References
PubMed ID Title Journal Year
5840415 Unspecific permeation and specific exchange of adenine nucleotides in

Heldt, HW, Pfaff, E, Klingenberg, M

Biochim Biophys Acta 1965
9587671 The mitochondrial ADP/ATP carrier: structural, physiological and

Schwimmer, C, Fiore, C, Roux, P, Vignais, PV, Brandolin, G, Lauquin, GJ, Trezeguet, V, Dianoux, AC, Noel, F, Le Saux, A

Biochimie 1998
5857365 [Exchange between extra- and intramitochondrial adenine nucleotides]

Vignais, PV, Duee, ED

Biochim Biophys Acta 1965
2648994 Molecular aspects of the adenine nucleotide carrier from mitochondria

Klingenberg, M

Arch Biochem Biophys 1989
Catalyst Activity

adenine transmembrane transporter activity of SLC25A5,6 dimers [mitochondrial inner membrane]

Orthologous Events
Cross References
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