Transfer of electrons through the succinate dehydrogenase complex

Stable Identifier
R-HSA-163213
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Succinate + Q10 => Fumarate + Q10H2
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Transfer of electrons through the succinate dehydrogenase complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
This event is deduced on the basis of bovine experimental data.
Complex II (succinate dehydrogenase) transfers electrons from the TCA cycle to ubiquinone. The 6th step in the TCA cycle is where succinate is dehydrogenated to fumarate with subsequent reduction of FAD to FADH2. FADH2 provides the electrons for the transport chain. Succinate dehydrogenase belongs to subclass 1 of the SQR family (succinate:quinone reductase) (classified by Hagerhall, C and Hederstedt, L [1996]).
It consists of 4 subunits (referred to as A, B, C and D), all nuclear-encoded and is located on the matrix side of the inner mitochondrial membrane. Subunits A and B are hydrophilic whereas subunits C and D are integral proteins of the inner membrane. SQRs usually contain 3 Fe-S clusters bound by the B subunit. Succinate dehydrogenase contains one [2Fe-2S] cluster, one [4Fe-4S] cluster and one [3Fe-4S] cluster. Additionally, the A subunit has a covalently-bound FAD group. Reduced complex II has this FAD converted to FADH2. The electrons from complex II are transferred to ubiquinone (also called Q, Coenzyme Q or CoQ), a small mobile carrier of electrons located within the inner membrane. Ubiquinone is reduced to ubiquinol during this process.

The mitochondrial heat shock protein 75 kDa (TRAP1) inhibits Complex II of the respiratory chain which elicits respiratory downregulation, leading to a pseudohypoxic state. This state is caused by succinate-dependent HIF1-alpha stabilisation which, in turn, can promote tumorigenesis (Sciacovelli et al. 2013, Yoshida et al. 2013, Guzzo et al. 2014).
Literature References
PubMed ID Title Journal Year
23747254 The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase

Defilippi, P, Nannini, N, Calabrese, F, Rasola, A, Laudiero, G, Bernardi, P, Guzzo, G, Frezza, C, Zheng, L, Esposito, F, Landriscina, M, Morello, V, Sciacovelli, M

Cell Metab. 2013
25564869 Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells

Rasola, A, Bernardi, P, Guzzo, G, Sciacovelli, M

Oncotarget 2014
23564345 Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

Lee, MJ, Miyajima, N, Picard, D, Trepel, J, Tsutsumi, S, Tatokoro, M, Hasumi, H, Koga, F, Muhlebach, G, Kihara, K, Beebe, K, Yoshida, S, Nakamura, K, Sourbier, C, Neckers, L, Fukushima, H, Chen, Y, Lee, S, Mohney, RP, Xu, W, Vartholomaiou, E

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
mitochondrial electron transport, succinate to ubiquinone (0006121)
Catalyst Activity

succinate dehydrogenase (quinone) activity of SDH complex [mitochondrial inner membrane]

Physical Entity
SDH complex [mitochondrial inner membrane] (Homo sapiens)
Activity
succinate dehydrogenase (quinone) activity (GO:0008177)
This event is regulated
Negatively by
Regulator
itaconate [mitochondrial matrix]
Regulator
TRAP1 [mitochondrial matrix] (Homo sapiens)
Inferred From
Transfer of electrons through the bovine succinate dehydrogenase complex (Bos taurus)
Cross References
RHEA
Authored
Jassal, B  (2005-06-10)
Reviewed
Hill, DP  (2024-05-16)
Created
Jassal, B  (2005-04-25)
Cite Us!