uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid

Stable Identifier
R-HSA-162729
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
ReviewStatus
5/5
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uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid
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The fatty acid group added to inositol in the fourth step of GPI biosynthsis is removed from GPI-conjugated uPAR. This hydrolysis event occurs in the endoplasmic reticulum and appears to be associated with efficient transport of the conjugated protein from the endoplasmic reticulum to the Golgi apparatus (Tanaka et al. 2004).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

hydrolase activity, acting on ester bonds of PGAP1 [endoplasmic reticulum membrane]

Physical Entity
PGAP1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
hydrolase activity, acting on ester bonds (GO:0016788)
Orthologous Events
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Bos taurus)
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Canis familiaris)
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Mus musculus)
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Rattus norvegicus)
uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid (Sus scrofa)
Authored
D'Eustachio, P  (2005-04-05)
Created
D'Eustachio, P  (2005-04-05)
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