Reactome | dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose

dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose

Stable Identifier

R-HSA-162721

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose => a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of dolichyl-phosphate mannose (Homo sapiens)
        
        dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)
  - Post-translational modification: synthesis of GPI-anchored proteins (Homo sapiens)
    - Synthesis of dolichyl-phosphate mannose (Homo sapiens)
      - dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)

General

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dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose

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Cytosolic GDP-mannose reacts with dolichyl phosphate in the endoplasmic reticulum membrane to form dolichyl phosphate D-mannose (DOLPman). The reaction is catalysed by dolichyl-phosphate mannosyltransferase, a heterotrimeric protein embedded in the endoplasmic reticulum membrane. The first subunit of the heterotrimer (DPM1) appears to be the actual catalyst, and the other two subunits appear to stabilise it (Maeda et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10835346	Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3 Maeda, Y, Tanaka, S, Hino, J, Kangawa, K, Kinoshita, T	EMBO J	2000