dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose

Stable Identifier
R-HSA-162721
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic GDP-mannose reacts with dolichyl phosphate in the endoplasmic reticulum membrane to form dolichyl phosphate D-mannose (DOLPman). The reaction is catalysed by dolichyl-phosphate mannosyltransferase, a heterotrimeric protein embedded in the endoplasmic reticulum membrane. The first subunit of the heterotrimer (DPM1) appears to be the actual catalyst, and the other two subunits appear to stabilise it (Maeda et al. 2000).

Literature References
PubMed ID Title Journal Year
10835346 Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3

Maeda, Y, Tanaka, S, Hino, J, Kangawa, K, Kinoshita, T

EMBO J 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dolichyl-phosphate beta-D-mannosyltransferase activity of DPM1:DPM2:DPM3 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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Created