Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane

Stable Identifier
R-HSA-162715
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic side of endoplasmic reticulum membrane, lumenal side of endoplasmic reticulum membrane
ReviewStatus
5/5
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Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane
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Dolichyl phosphate D-mannose (DOLPman) is flipped in the endoplasmic reticulum membrane so that its mannose moiety is oriented inwards, towards the endoplasmic reticulum lumen, where it is accessible to transferases catalyzing the synthesis of glycolipids and glycoproteins (Kinoshita & Inoue 2000).
Literature References
PubMed ID Title Journal Year
11102867 Dissecting and manipulating the pathway for glycosylphosphatidylinositol-anchor biosynthesis

Kinoshita, T, Inoue, N

Curr Opin Chem Biol 2000
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Authored
Dall'Olio, GM  (2009-11-10)
Reviewed
Gagneux, P  (2010-04-16)
Created
D'Eustachio, P  (2005-04-05)
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