Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane

Stable Identifier
R-HSA-162715
Type
Reaction [transition]
Species
Homo sapiens
Compartment
integral component of cytoplasmic side of endoplasmic reticulum membrane, integral component of lumenal side of endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Reorientation of dolichyl phosphate D-mannose in the endoplasmic reticulum membrane
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dolichyl phosphate D-mannose (DOLPman) is flipped in the endoplasmic reticulum membrane so that its mannose moiety is oriented inwards, towards the endoplasmic reticulum lumen, where it is accessible to transferases catalyzing the synthesis of glycolipids and glycoproteins (Kinoshita & Inoue 2000).

Literature References
PubMed ID Title Journal Year
11102867 Dissecting and manipulating the pathway for glycosylphosphatidylinositol-anchor biosynthesis

Kinoshita, T, Inoue, N

Curr Opin Chem Biol 2000
Participants
Input
Output
Participates
as an event of
Authored
Dall'Olio, GM  (2009-11-10)
Reviewed
Gagneux, P  (2010-04-16)
Created
D'Eustachio, P  (2005-04-05)
Cite Us!