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HIV Life Cycle
Stable Identifier
R-HSA-162587
DOI
10.3180/REACT_6256.3
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
ReviewStatus
5/5
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HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
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The life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the
early
phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surface (a), viral and host cell membranes fuse and the viral particle is uncoated (b), the viral genome is reverse transcribed and the viral preintegration complex (PIC) forms (c), the PIC is transported through the nuclear pore into the nucleoplasm (d), and the viral reverse transcript is integrated into a host cell chromosome (e). In the
late
phase, viral RNAs are transcribed from the integrated viral genome and processed to generate viral mRNAs and full-length viral genomic RNAs (f), the viral RNAs are exported through the nuclear pore into the cytosol (g), viral mRNAs are translated and the resulting viral proteins are post-translationally processed (h), core particles containing viral genomic RNA and proteins assemble at the host cell membrane and immature viral particles are released by budding. The released particles mature to become infectious (j), completing the cycle (Frankel and Young 1998; Miller and Bushman 1997).
Most of the crucial concepts used to describe these processes were originally elucidated in studies of retroviruses associated with tumors in chickens, birds, and other animal model systems, and the rapid elucidation of the basic features of the HIV-1 life cycle was critically dependent on the intellectual framework provided by these earlier studies. This earlier work has been very well summarized (e.g., Weiss et al. 1984; Coffin et al. 1997); here for brevity and clarity we focus on experimental studies specific to the HIV-1 life cycle.
Literature References
PubMed ID
Title
Journal
Year
Retroviruses
Varmus, HE
,
Hughes, SH
,
Coffin, JM
1997
9188609
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition
Miller, MD
,
Bushman, FD
J Virol
1997
9759480
HIV-1: fifteen proteins and an RNA
Frankel, AD
,
Young, JA
Annu Rev Biochem
1998
Participants
Events
Early Phase of HIV Life Cycle
(Homo sapiens)
Late Phase of HIV Life Cycle
(Homo sapiens)
Participates
as an event of
HIV Infection (Homo sapiens)
Event Information
Go Biological Process
viral process (0016032)
Disease
Name
Identifier
Synonyms
Human immunodeficiency virus infectious disease
DOID:526
HIV infection
Authored
Gopinathrao, G (2015-01-13)
Iordanskiy, S (2015-01-13)
Morrow, MP (2015-01-13)
Bukrinsky, M (2015-01-13)
Rice, AP (2015-01-13)
Matthews, L (2015-01-13)
D'Eustachio, P (2015-01-13)
Gillespie, ME (2015-01-13)
Created
Joshi-Tope, G (2005-04-01)
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