MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA

Stable Identifier
R-HSA-1606682
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
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MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
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Translation of NOTCH1 mRNA is inhibited by MIR34 microRNAs (MIR34A, MIR34B and MIR34C), which bind to the 3'UTR of NOTCH1 mRNA. Expression of MIR34 microRNAs is directly regulated by the p53 (TP53) tumor suppressor gene (Chang et al. 2007, Raver-Shapira et al. 2007), and MIR34-mediated downregulation of NOTCH1 signaling is thought to negatively regulate cell survival, motility and maintenance of an undifferentiated state.

Literature References
PubMed ID Title Journal Year
20351093 MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells

Pang, RT, Leung, CON, Ye, TM, Liu, W, Chiu, PCN, Lam, KKW, Lee, KF, Yeung, WS

Carcinogenesis 2010
17540598 Transcriptional activation of miR-34a contributes to p53-mediated apoptosis

Raver-Shapira, N, Marciano, E, Meiri, E, Spector, Y, Rosenfeld, N, Moskovits, N, Bentwich, Z, Oren, M

Mol Cell 2007
17540599 Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

Chang, TC, Wentzel, EA, Kent, OA, Ramachandran, K, Mullendore, M, Lee, KH, Feldmann, G, Yamakuchi, M, Ferlito, M, Lowenstein, CJ, Arking, DE, Beer, MA, Maitra, A, Mendell, JT

Mol Cell 2007
19773441 MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes

Li, Y, Guessous, F, Zhang, Y, DiPierro, C, Kefas, B, Johnson, E, Marcinkiewicz, L, Jiang, J, Yang, Y, Schmittgen, TD, Lopes, B, Schiff, D, Purow, B, Abounader, R

Cancer Res 2009
19714243 MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells

Ji, Q, Hao, X, Zhang, M, Tang, W, Meng, Y, Li, L, Xiang, D, DeSano, JT, Bommer, GT, Fan, D, Fearon, ER, Lawrence, TS, Xu, L

PLoS One 2009
Participants
Input
Output
Participant Of
hasEvent
Authored
Egan, SE  (2011-11-14)
Orlic-Milacic, M  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-09-23)