Activation of MMP9 intermediate form by MMPs

Stable Identifier
R-HSA-1604690
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The intermediate form of MMP9 is activated by cleavage of the Arg106-Phe107 peptide bond producing the fullly active 82-kDa MMP-9 species (Ogata et al. 1992, Fridman et al. 1995).

Literature References
PubMed ID Title Journal Year
7780967 Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2)

Fridman, R, Toth, M, Peña, D, Mobashery, S

Cancer Res 1995
1371271 Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9

Ogata, Y, Enghild, JJ, Nagase, H

J Biol Chem 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP1 (2, 3, 7, 10, 13) [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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